化工社化工社 化学情報印刷レポート · 研究参考用
3-Chloro-4-fluorobenzamide → 4-(4-Carbamoyl-2-chlorophenyloxy)-7-(2,2,2-trifluoroethyl)-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Chloro-4-fluorobenzamide | HCID 2736520 | — |
| 反応物 | 7-(2,2,2-trifluoroethyl)-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol | HCID 68410019 | — |
| 生成物 | 4-(4-Carbamoyl-2-chlorophenyloxy)-7-(2,2,2-trifluoroethyl)-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepine hydrochloride | HCID 68409911 | — |
反応手順
The same method as in Example 3 was conducted using 7-(2,2,2-trifluoroethyl)-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol (Reference Example 38) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 4-carbamoyl-2-chloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08217031B2 |
| 出典データセット | uspto-grants-2012_07 |
| ORD ID | ord-9c275ed1a84647ab8bb292ef9d829fef |
| 出典メモ | uspto-grants-2012_07 |