3-Chloro-4-fluorobenzamide → HCID 68411219, compound

HRID 1511728Notes

Reaction equation

HRID 1511728 reaction equation
[CH:1]1([CH2:4][N:5]2[CH2:11][CH2:10][CH:9]([OH:12])[C:8]3[CH:13]=[CH:14][O:15][C:7]=3[CH2:6]2)[CH2:3][CH2:2]1.[C:16]([C:19]1[CH:24]=[CH:23][C:22](F)=[C:21]([Cl:26])[CH:20]=1)(=[O:18])[NH2:17]>>[ClH:26].[C:16]([C:19]1[CH:24]=[CH:23][C:22]([O:12][CH:9]2[CH2:10][CH2:11][N:5]([CH2:4][CH:1]3[CH2:2][CH2:3]3)[CH2:6][C:7]3[O:15][CH:14]=[CH:13][C:8]2=3)=[C:21]([Cl:26])[CH:20]=1)(=[O:18])[NH2:17]

Participants

3

Reactant 2

HCID 27365203-Chloro-4-fluorobenzamideHCID 68412220HCID 68412220, compound

Product 1

HCID 68411219HCID 68411219, compound

Procedure

The same method as in Example 3 was conducted using 7-cyclopropylmethyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol (Reference Example 39) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 4-carbamoyl-2-chloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-b2de0baf30a14fc5a6fbdfba75d0d280
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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