3-Chloro-4-fluorobenzamide → HCID 68410062, compound

HRID 1511732Notes

Reaction equation

HRID 1511732 reaction equation
[Cl:1][C:2]1[S:13][C:5]2[CH2:6][N:7]([CH3:12])[CH2:8][CH2:9][CH:10]([OH:11])[C:4]=2[CH:3]=1.[C:14]([C:17]1[CH:22]=[CH:21][C:20](F)=[C:19]([Cl:24])[CH:18]=1)(=[O:16])[NH2:15]>>[ClH:1].[C:14]([C:17]1[CH:22]=[CH:21][C:20]([O:11][CH:10]2[CH2:9][CH2:8][N:7]([CH3:12])[CH2:6][C:5]3[S:13][C:2]([Cl:1])=[CH:3][C:4]2=3)=[C:19]([Cl:24])[CH:18]=1)(=[O:16])[NH2:15]

Participants

3

Reactant 2

HCID 27365203-Chloro-4-fluorobenzamideHCID 68410743HCID 68410743, compound

Product 1

HCID 68410062HCID 68410062, compound

Procedure

The same method as in Example 3 was conducted using 2-chloro-7-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepin-4-ol (Reference Example 24) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 4-carbamoyl-2-chloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-adf4040f100d4509afb023d42b3696f3
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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