1-Bromo-2-chloro-3-fluorobenzene → HCID 86639231, compound

HRID 1511733Notes

Reaction equation

HRID 1511733 reaction equation
[C:1]([CH2:3][N:4]1[CH2:10][CH2:9][CH:8]([OH:11])[C:7]2[CH:12]=[CH:13][O:14][C:6]=2[CH2:5]1)#[N:2].[Br:15][C:16]1[C:17]([Cl:23])=[C:18](F)[CH:19]=[CH:20][CH:21]=1>>[ClH:23].[Br:15][C:16]1[C:17]([Cl:23])=[C:18]([O:11][CH:8]2[CH2:9][CH2:10][N:4]([CH2:3][C:1]#[N:2])[CH2:5][C:6]3[O:14][CH:13]=[CH:12][C:7]2=3)[CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 37393011-Bromo-2-chloro-3-fluorobenzeneHCID 86639233HCID 86639233, compound

Product 1

HCID 86639231HCID 86639231, compound

Procedure

The same method as in Example 3 was conducted using 7-cyanomethyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol (Reference Example 41) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3-bromo-2-chloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-3b2712c0b0164e57ad9356c415ebb6b4
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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