1-Bromo-2-chloro-3-fluorobenzene → HCID 68414062, compound

HRID 1511734Notes

Reaction equation

HRID 1511734 reaction equation
[CH2:1]([O:3][C:4]([CH2:6][N:7]1[CH2:13][CH2:12][CH:11]([OH:14])[C:10]2[CH:15]=[CH:16][O:17][C:9]=2[CH2:8]1)=[O:5])[CH3:2].[Br:18][C:19]1[C:20]([Cl:26])=[C:21](F)[CH:22]=[CH:23][CH:24]=1>>[ClH:26].[Br:18][C:19]1[C:20]([Cl:26])=[C:21]([O:14][CH:11]2[CH2:12][CH2:13][N:7]([CH2:6][C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH2:8][C:9]3[O:17][CH:16]=[CH:15][C:10]2=3)[CH:22]=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 37393011-Bromo-2-chloro-3-fluorobenzeneHCID 68409600HCID 68409600, compound

Product 1

HCID 68414062HCID 68414062, compound

Procedure

The same method as in Example 3 was conducted using 7-ethoxycarbonylmethyl-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol (Reference Example 42) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3-bromo-2-chloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-be15aa0a7dd64425a124af7c6e76df47
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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