1-Bromo-2-chloro-3-fluorobenzene → HCID 68410070, compound

HRID 1511735Notes

Reaction equation

HRID 1511735 reaction equation
[OH:1][C:2]([CH3:16])([CH3:15])[CH2:3][N:4]1[CH2:10][CH2:9][CH:8]([OH:11])[C:7]2[CH:12]=[CH:13][O:14][C:6]=2[CH2:5]1.[Br:17][C:18]1[C:19]([Cl:25])=[C:20](F)[CH:21]=[CH:22][CH:23]=1>>[ClH:25].[Br:17][C:18]1[C:19]([Cl:25])=[C:20]([O:11][CH:8]2[CH2:9][CH2:10][N:4]([CH2:3][C:2]([OH:1])([CH3:16])[CH3:15])[CH2:5][C:6]3[O:14][CH:13]=[CH:12][C:7]2=3)[CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 37393011-Bromo-2-chloro-3-fluorobenzeneHCID 68411595HCID 68411595, compound

Product 1

HCID 68410070HCID 68410070, compound

Procedure

The same method as in Example 3 was conducted using 7-(2-hydroxy-2-methyl-1-propyl)-5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol (Reference Example 43) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3-bromo-2-chloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-070ed3a847ef4ce9b9fb723f51f083be
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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