3-Chloro-4-fluorobenzamide → HCID 68413939, compound

HRID 1511737Notes

Reaction equation

HRID 1511737 reaction equation
[O:1]1[C:5]2[CH2:6][NH:7][CH2:8][CH2:9][CH:10]([OH:11])[C:4]=2[CH:3]=[CH:2]1.[C:12]([C:15]1[CH:20]=[CH:19][C:18](F)=[C:17]([Cl:22])[CH:16]=1)(=[O:14])[NH2:13]>>[ClH:22].[C:12]([C:15]1[CH:20]=[CH:19][C:18]([O:11][CH:10]2[CH2:9][CH2:8][NH:7][CH2:6][C:5]3[O:1][CH:2]=[CH:3][C:4]2=3)=[C:17]([Cl:22])[CH:16]=1)(=[O:14])[NH2:13]

Participants

3

Reactant 2

HCID 27365203-Chloro-4-fluorobenzamideHCID 68411564HCID 68411564, compound

Product 1

HCID 68413939HCID 68413939, compound

Procedure

The same method as in Example 3 was conducted using 5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol (Reference Example 37) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 4-carbamoyl-2-chloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-b83b148c067d42539a96341e073e1780
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

Loading…