Benzene, 1,2-dichloro-3-fluoro- → HCID 68410816, compound

HRID 1511738Notes

Reaction equation

HRID 1511738 reaction equation
[S:1]1[C:5]2[CH2:6][NH:7][CH2:8][CH2:9][CH:10]([OH:11])[C:4]=2[CH:3]=[CH:2]1.[Cl:12][C:13]1[C:18]([Cl:19])=[CH:17][CH:16]=[CH:15][C:14]=1F>>[ClH:12].[Cl:12][C:13]1[C:18]([Cl:19])=[CH:17][CH:16]=[CH:15][C:14]=1[O:11][CH:10]1[CH2:9][CH2:8][NH:7][CH2:6][C:5]2[S:1][CH:2]=[CH:3][C:4]1=2

Participants

3

Reactant 2

HCID 119011Benzene, 1,2-dichloro-3-fluoro-HCID 68412204HCID 68412204, compound

Product 1

HCID 68410816HCID 68410816, compound

Procedure

The same method as in Example 3 was conducted using 5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepin-4-ol (Reference Example 35) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 2,3-dichloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-03cd0c53de9d47c083160b740959fd21
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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