1-Bromo-2-chloro-3-fluorobenzene → HCID 68409382, compound

HRID 1511739Notes

Reaction equation

HRID 1511739 reaction equation
[S:1]1[C:5]2[CH2:6][NH:7][CH2:8][CH2:9][CH:10]([OH:11])[C:4]=2[CH:3]=[CH:2]1.[Br:12][C:13]1[C:14]([Cl:20])=[C:15](F)[CH:16]=[CH:17][CH:18]=1>>[ClH:20].[Br:12][C:13]1[C:14]([Cl:20])=[C:15]([O:11][CH:10]2[CH2:9][CH2:8][NH:7][CH2:6][C:5]3[S:1][CH:2]=[CH:3][C:4]2=3)[CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 37393011-Bromo-2-chloro-3-fluorobenzeneHCID 68412204HCID 68412204, compound

Product 1

HCID 68409382HCID 68409382, compound

Procedure

The same method as in Example 3 was conducted using 5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepin-4-ol (Reference Example 35) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3-bromo-2-chloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-96e286cdd7ed4918b32af8ced3c04e9f
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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