HCID 68411564, compound → HCID 68411811, compound

HRID 1511742Notes

Reaction equation

HRID 1511742 reaction equation
[O:1]1[C:5]2[CH2:6][NH:7][CH2:8][CH2:9][CH:10]([OH:11])[C:4]=2[CH:3]=[CH:2]1.[CH2:12]([O:19][C:20]1[CH:25]=[CH:24][C:23](F)=[C:22]([Cl:27])[C:21]=1[Br:28])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[ClH:27].[CH2:12]([O:19][C:20]1[CH:25]=[CH:24][C:23]([O:11][CH:10]2[CH2:9][CH2:8][NH:7][CH2:6][C:5]3[O:1][CH:2]=[CH:3][C:4]2=3)=[C:22]([Cl:27])[C:21]=1[Br:28])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 68411564HCID 68411564, compoundHCID 68412287HCID 68412287, compound

Product 1

HCID 68411811HCID 68411811, compound

Procedure

The same method as in Example 3 was conducted using 5,6,7,8-tetrahydro-4H-furo[2,3-c]azepin-4-ol (Reference Example 37) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 4-benzyloxy-3-bromo-2-chloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-2d64fc8c68c74cbbbf181c8cf2374234
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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