3-Chloro-4-fluorobenzamide → HCID 68411878, compound

HRID 1511746Notes

Reaction equation

HRID 1511746 reaction equation
[CH3:1][C:2]1[S:10][C:9]2[CH:8]([OH:11])[CH2:7][NH:6][CH2:5][C:4]=2[CH:3]=1.[C:12]([C:15]1[CH:20]=[CH:19][C:18](F)=[C:17]([Cl:22])[CH:16]=1)(=[O:14])[NH2:13]>>[C:12]([C:15]1[CH:20]=[CH:19][C:18]([O:11][CH:8]2[CH2:7][NH:6][CH2:5][C:4]3[CH:3]=[C:2]([CH3:1])[S:10][C:9]2=3)=[C:17]([Cl:22])[CH:16]=1)(=[O:14])[NH2:13]

Participants

3

Reactant 2

HCID 27365203-Chloro-4-fluorobenzamideHCID 684104592-Methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-ol

Product 1

HCID 68411878HCID 68411878, compound

Procedure

The same method as in Example 1 was conducted using 2-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-ol (Reference Example 30) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 4-carbamoyl-2-chloro-1-fluorobenzene instead of 1-fluoronaphthalene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-9fb42108ba6c4fa4ad73cf4fe2cb88cf
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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