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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1511749Generated: October 25, 2026

1-Bromo-2-chloro-3-fluorobenzene → 7-(3-Bromo-2-chlorophenyloxy)-5-ethyl-2-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

https://huagongshe.com/reaction/1511749

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-2-chloro-3-fluorobenzeneHCID 3739301—
Reactant5-Ethyl-2-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-olHCID 68412460—
Product7-(3-Bromo-2-chlorophenyloxy)-5-ethyl-2-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridineHCID 68412083—

Reaction Steps

The same method as in Example 1 was conducted using 5-ethyl-2-methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-7-ol (Reference Example 32) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3-bromo-2-chloro-1-fluorobenzene instead of 1-fluoronaphthalene to give the objective compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08217031B2
Source datasetuspto-grants-2012_07
ORD IDord-bbe6dfa9658348dc8cb1f980cafbf533
Source noteuspto-grants-2012_07