1,2-Dichloro-4-fluorobenzene → HCID 68411491, compound

HRID 1511758Notes

Reaction equation

HRID 1511758 reaction equation
[S:1]1[C:5]2[CH2:6][CH2:7][NH:8][CH2:9][CH:10]([OH:11])[C:4]=2[CH:3]=[CH:2]1.[Cl:12][C:13]1[CH:14]=[C:15](F)[CH:16]=[CH:17][C:18]=1[Cl:19]>>[ClH:12].[Cl:12][C:13]1[CH:14]=[C:15]([O:11][CH:10]2[CH2:9][NH:8][CH2:7][CH2:6][C:5]3[S:1][CH:2]=[CH:3][C:4]2=3)[CH:16]=[CH:17][C:18]=1[Cl:19]

Participants

3

Reactant 2

HCID 740281,2-Dichloro-4-fluorobenzeneHCID 116368784H-Thieno[2,3-d]azepin-4-ol, 5,6,7,8-tetrahydro-

Product 1

HCID 68411491HCID 68411491, compound

Procedure

The same method as in Example 3 was conducted using 5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepin-4-ol (Reference Example 29) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3,4-dichloro-1-fluorobenzene instead of 1,3-difluorobenzene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-33b123d60ae94e559a699e552918431d
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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