1-Bromo-2-chloro-3-fluorobenzene → 4-(3-Bromo-2-chlorophenyloxy)-6-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepine

HRID 1511761Notes

Reaction equation

HRID 1511761 reaction equation
[CH3:1][N:2]1[CH2:8][CH:7]([OH:9])[C:6]2[CH:10]=[CH:11][S:12][C:5]=2[CH2:4][CH2:3]1.[Br:13][C:14]1[C:15]([Cl:21])=[C:16](F)[CH:17]=[CH:18][CH:19]=1>>[Br:13][C:14]1[C:15]([Cl:21])=[C:16]([O:9][CH:7]2[CH2:8][N:2]([CH3:1])[CH2:3][CH2:4][C:5]3[S:12][CH:11]=[CH:10][C:6]2=3)[CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 37393011-Bromo-2-chloro-3-fluorobenzeneHCID 684099986-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepin-4-ol

Product 1

HCID 684118844-(3-Bromo-2-chlorophenyloxy)-6-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepine

Procedure

The same method as in Example 1 was conducted using 6-methyl-5,6,7,8-tetrahydro-4H-thieno[2,3-d]azepin-4-ol (Reference Example 28) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3-bromo-2-chloro-1-fluorobenzene instead of 1-fluoronaphthalene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-8bb75edb453d4fc5853cfaf2205ff376
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

Loading…