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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1511770Generated: November 4, 2026

1-Bromo-2-fluorobenzene → 7-(2-Bromophenyloxy)-4,5,6,7-tetrahydrofuro[3,2-c]pyridine

https://huagongshe.com/reaction/1511770

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-2-fluorobenzeneHCID 61259—
Reactant4,5,6,7-Tetrahydrofuro[3,2-c]pyridin-7-olHCID 55300159—
Product7-(2-Bromophenyloxy)-4,5,6,7-tetrahydrofuro[3,2-c]pyridineHCID 68412180—

Reaction Steps

The same method as in Example 1 was conducted using 4,5,6,7-tetrahydrofuro[3,2-c]pyridin-7-ol (Reference Example 33) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 2-bromo-1-fluorobenzene instead of 1-fluoronaphthalene to give the objective compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08217031B2
Source datasetuspto-grants-2012_07
ORD IDord-9085185eae25457a9d79da253daca24b
Source noteuspto-grants-2012_07