3-Chloro-4-fluorobenzamide → 7-(4-Carbamoyl-2-chlorophenyloxy)-4,5,6,7-tetrahydrofuro[3,2-c]pyridine

HRID 1511771Notes

Reaction equation

HRID 1511771 reaction equation
[O:1]1[C:9]2[CH:8]([OH:10])[CH2:7][NH:6][CH2:5][C:4]=2[CH:3]=[CH:2]1.[C:11]([C:14]1[CH:19]=[CH:18][C:17](F)=[C:16]([Cl:21])[CH:15]=1)(=[O:13])[NH2:12]>>[C:11]([C:14]1[CH:19]=[CH:18][C:17]([O:10][CH:8]2[CH2:7][NH:6][CH2:5][C:4]3[CH:3]=[CH:2][O:1][C:9]2=3)=[C:16]([Cl:21])[CH:15]=1)(=[O:13])[NH2:12]

Participants

3

Reactant 2

HCID 27365203-Chloro-4-fluorobenzamideHCID 553001594,5,6,7-Tetrahydrofuro[3,2-c]pyridin-7-ol

Product 1

HCID 684096917-(4-Carbamoyl-2-chlorophenyloxy)-4,5,6,7-tetrahydrofuro[3,2-c]pyridine

Procedure

The same method as in Example 1 was conducted using 4,5,6,7-tetrahydrofuro[3,2-c]pyridin-7-ol (Reference Example 33) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 4-carbamoyl-2-chloro-1-fluorobenzene instead of 1-fluoronaphthalene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-fb9e39f311d04075bf491bf4d875b21e
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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