1,2-Dichloro-4-fluorobenzene → 7-(3,4-Dichlorophenyloxy)-5-ethyl-4,5,6,7-tetrahydrofuro[3,2-c]pyridine

HRID 1511773Notes

Reaction equation

HRID 1511773 reaction equation
[CH2:1]([N:3]1[CH2:8][CH:7]([OH:9])[C:6]2[O:10][CH:11]=[CH:12][C:5]=2[CH2:4]1)[CH3:2].[Cl:13][C:14]1[CH:15]=[C:16](F)[CH:17]=[CH:18][C:19]=1[Cl:20]>>[Cl:13][C:14]1[CH:15]=[C:16]([O:9][CH:7]2[CH2:8][N:3]([CH2:1][CH3:2])[CH2:4][C:5]3[CH:12]=[CH:11][O:10][C:6]2=3)[CH:17]=[CH:18][C:19]=1[Cl:20]

Participants

3

Reactant 2

HCID 740281,2-Dichloro-4-fluorobenzeneHCID 684101205-Ethyl-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-7-ol

Product 1

HCID 684099477-(3,4-Dichlorophenyloxy)-5-ethyl-4,5,6,7-tetrahydrofuro[3,2-c]pyridine

Procedure

The same method as in Example 1 was conducted using 5-ethyl-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-7-ol (Reference Example 34) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3,4-dichloro-1-fluorobenzene instead of 1-fluoronaphthalene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-b5015ed1fea64cac985e14c96ea543b5
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

Loading…