1-Bromo-2-chloro-3-fluorobenzene → 7-(3-Bromo-2-chlorophenyloxy)-5-ethyl-4,5,6,7-tetrahydrofuro[3,2-c]pyridine

HRID 1511774Notes

Reaction equation

HRID 1511774 reaction equation
[CH2:1]([N:3]1[CH2:8][CH:7]([OH:9])[C:6]2[O:10][CH:11]=[CH:12][C:5]=2[CH2:4]1)[CH3:2].[Br:13][C:14]1[C:15]([Cl:21])=[C:16](F)[CH:17]=[CH:18][CH:19]=1>>[Br:13][C:14]1[C:15]([Cl:21])=[C:16]([O:9][CH:7]2[CH2:8][N:3]([CH2:1][CH3:2])[CH2:4][C:5]3[CH:12]=[CH:11][O:10][C:6]2=3)[CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 37393011-Bromo-2-chloro-3-fluorobenzeneHCID 684101205-Ethyl-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-7-ol

Product 1

HCID 684099787-(3-Bromo-2-chlorophenyloxy)-5-ethyl-4,5,6,7-tetrahydrofuro[3,2-c]pyridine

Procedure

The same method as in Example 1 was conducted using 5-ethyl-4,5,6,7-tetrahydrofuro[3,2-c]pyridin-7-ol (Reference Example 34) instead of 6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-4-ol (Reference Example 6) and was conducted using 3-bromo-2-chloro-1-fluorobenzene instead of 1-fluoronaphthalene to give the objective compound.

Workup

  1. customto give the objective compound

Sources & evidence

ORD record
ord-a318aae21acd419094afa4450dad357a
Source dataset
uspto-grants-2012_07
Patent number
US08217031B2

Reaction notes

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