化工社化工社 化学情報印刷レポート · 研究参考用
(S)-(+)-Glycidyl butyrate → (S)-3-(3-Fluoro-4-methyl-phenyl)-5-hydroxymethyl-oxazolidin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (S)-(+)-Glycidyl butyrate | HCID 6999819 | — |
| 反応物 | (3-Fluoro-4-methyl-phenyl)-carbamic acid benzyl ester | HCID 66737113 | — |
| 生成物 | (S)-3-(3-Fluoro-4-methyl-phenyl)-5-hydroxymethyl-oxazolidin-2-one | HCID 66953644 | — |
反応手順
Starting from (3-fluoro-4-methyl-phenyl)-carbamic acid benzyl ester (prepared from 3-fluoro-4-methyl-aniline and CbzCl according to procedure C) and (S)-glycidyl butyrate and following the procedure described for the preparation of intermediate 1.iii)(procedure D), the title compound was obtained as a yellow solid (4.16 g, 65%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08217029B2 |
| 出典データセット | uspto-grants-2012_07 |
| ORD ID | ord-eafed1288c134b76841feaba21714d9a |
| 出典メモ | uspto-grants-2012_07 |