6-Methoxy-1,5-naphthyridin-4-yl trifluoromethanesulfonate → HCID 66954614, compound

HRID 1511790Notes

Reaction equation

HRID 1511790 reaction equation
[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[C:6]2OS(C(F)(F)F)(=O)=O.[CH2:21]([O:28][C:29](=[O:35])[NH:30][CH:31]1[CH2:34][NH:33][CH2:32]1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>CCOCC>[CH2:21]([O:28][C:29](=[O:35])[NH:30][CH:31]1[CH2:34][N:33]([C:6]2[C:5]3[C:10](=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[N:4]=3)[N:9]=[CH:8][CH:7]=2)[CH2:32]1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

4

Reactant 2

HCID 112552656-Methoxy-1,5-naphthyridin-4-yl trifluoromethanesulfonateHCID 17750122Benzyl azetidin-3-ylcarbamate

Product 1

HCID 66954614HCID 66954614, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

According to procedure F and starting from trifluoromethanesulfonic acid 6-methoxy-[1,5]naphthyridin-4-yl ester (prepared according to WO 02/008224) and azetidin-3-yl-carbamic acid benzyl ester the desired intermediate was isolated after trituration with ether as a colorless solid (5.05 g, 71%).

Sources & evidence

ORD record
ord-b4562622305640919db4234ba4c892d9
Source dataset
uspto-grants-2012_07
Patent number
US08217029B2

Reaction notes

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