(3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidine → HCID 66954740, compound

HRID 1511791Notes

Reaction equation

HRID 1511791 reaction equation
Br[C:2]1[C:3]([F:14])=[CH:4][N:5]=[C:6]2[C:11]=1[N:10]=[C:9]([O:12][CH3:13])[CH:8]=[CH:7]2.[C:15]([O:19][C:20]([NH:22][C@H:23]1[CH2:27][CH2:26][NH:25][CH2:24]1)=[O:21])([CH3:18])([CH3:17])[CH3:16]>>[C:15]([O:19][C:20](=[O:21])[NH:22][C@H:23]1[CH2:27][CH2:26][N:25]([C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[N:10]=3)[N:5]=[CH:4][C:3]=2[F:14])[CH2:24]1)([CH3:18])([CH3:16])[CH3:17]

Participants

3

Reactant 2

HCID 1514396(3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidineHCID 454803208-Bromo-7-fluoro-2-methoxy-1,5-naphthyridine

Product 1

HCID 66954740HCID 66954740, compoundYield 48%

Procedure

According to procedure F and starting from 8-bromo-7-fluoro-2-methoxy-[1,5]naphthyridine and (S)-(−)-3-(tert-butoxycarbonylamino)pyrrolidine the title intermediate was isolated as a yellow oil (304 mg, 48%).

Sources & evidence

ORD record
ord-7ddd669a57354486b50a2a6af3d73b24
Source dataset
uspto-grants-2012_07
Patent number
US08217029B2

Reaction notes

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