Benzyl 1,4-diazepane-1-carboxylate → 4-(6-Methoxy-[1,5]naphthyridin-4-yl)-[1,4]diazepane-1-carboxylic acid benzyl ester

HRID 1511800Notes

Reaction equation

HRID 1511800 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:17][CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[C:19]1[CH:20]=[CH:21][N:22]=[C:23]2[C:28]=1[N:27]=[C:26]([O:29][CH3:30])[CH:25]=[CH:24]2>>[CH2:1]([O:8][C:9]([N:11]1[CH2:17][CH2:16][CH2:15][N:14]([C:19]2[C:28]3[C:23](=[CH:24][CH:25]=[C:26]([O:29][CH3:30])[N:27]=3)[N:22]=[CH:21][CH:20]=2)[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 4384955Benzyl 1,4-diazepane-1-carboxylateHCID 534216178-Bromo-2-methoxy-1,5-naphthyridine

Product 1

HCID 669536544-(6-Methoxy-[1,5]naphthyridin-4-yl)-[1,4]diazepane-1-carboxylic acid benzyl ester

Procedure

According to procedure F and starting from [1,4]diazepane-1-carboxylic acid benzyl ester and 8-bromo-2-methoxy-[1,5]naphthyridine the title compound was isolated as a brown oil (4.18 g, 62%).

Sources & evidence

ORD record
ord-2c33291f38304d72a3ea2c2072711aaa
Source dataset
uspto-grants-2012_07
Patent number
US08217029B2

Reaction notes

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