HCID 2194922, compound → HCID 1501990, compound

HRID 1511809Notes

Reaction equation

HRID 1511809 reaction equation
[CH2:1]([O:8][C:9](=[O:19])[NH:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=1)[C:2]1C=CC=CC=1.[C:20](OC[C@H]1OC1)(=[O:24])CCC>>[OH:24][CH2:20][C@H:1]1[O:8][C:9](=[O:19])[N:10]([C:11]2[CH:12]=[CH:13][C:14]([O:17][CH3:18])=[CH:15][CH:16]=2)[CH2:2]1

Participants

3

Reactant 2

HCID 2194922HCID 2194922, compoundHCID 6999819(S)-(+)-Glycidyl butyrate

Product 1

HCID 1501990HCID 1501990, compound

Procedure

Starting from (4-methoxy-phenyl)-carbamic acid benzyl ester (prepared from 4-methoxy-aniline and CbzCl according to procedure C) and (S)-glycidyl butyrate and following the procedure described for the preparation of intermediate 1.iii), the title compound was obtained as a grey solid (469 mg, 54%).

Sources & evidence

ORD record
ord-396ad45416f64a82b1022e8a716c2f85
Source dataset
uspto-grants-2012_07
Patent number
US08217029B2

Reaction notes

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