(3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine → HCID 66954813, compound

HRID 1511811Notes

Reaction equation

HRID 1511811 reaction equation
Br[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([F:12])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.C(OC(=O)[NH:19][C@@H:20]1[CH2:24][CH2:23][NH:22][CH2:21]1)(C)(C)C>>[F:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][CH:3]=[C:2]2[N:22]1[CH2:23][CH2:24][C@@H:20]([NH2:19])[CH2:21]1

Participants

3

Reactant 2

HCID 1514397(3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidineHCID 179763184-Bromo-6-fluoroquinoline

Product 1

HCID 66954813HCID 66954813, compound

Procedure

Starting from 4-bromo-6-fluoroquinoline (commercial) and (R)-pyrrolidin-3-yl-carbamic acid tert-butyl ester (commercial) the title compound was prepared according to procedure F followed by procedure E and was isolated as a yellow solid (212 mg, 43% over two steps).

Sources & evidence

ORD record
ord-9a73f90f40364e34acd7ee4296387127
Source dataset
uspto-grants-2012_07
Patent number
US08217029B2

Reaction notes

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