4-(N-Boc-amino)piperidine → HCID 66954339, compound

HRID 1511813Notes

Reaction equation

HRID 1511813 reaction equation
Br[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([F:12])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.C(OC(=O)[NH:19][CH:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)(C)(C)C>>[F:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][CH:3]=[C:2]2[N:23]1[CH2:24][CH2:25][CH:20]([NH2:19])[CH2:21][CH2:22]1

Participants

3

Reactant 2

HCID 7238334-(N-Boc-amino)piperidineHCID 179763184-Bromo-6-fluoroquinoline

Product 1

HCID 66954339HCID 66954339, compound

Procedure

Starting from 4-bromo-6-fluoroquinoline (commercial) and piperidin-4-yl-carbamic acid tert-butyl ester (commercial) the title compound was prepared according to procedure F followed by procedure E and was isolated as a yellow solid (223 mg, 40% over two steps).

Sources & evidence

ORD record
ord-7d648046cc874ff780c00fc5eb39e2df
Source dataset
uspto-grants-2012_07
Patent number
US08217029B2

Reaction notes

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