Methanol → 3-m-Anisyl-1-propanol

A solution of 3-(3-methoxyphenyl)propanoic acid (2.00 g, 11.10 mmol) in THF (2.0 mL) was added dropwise to a stirred solution of borane-tetrahydrofuran complex (24.42 mL, 24.42 mmol) so as to maintain reaction temperature below 35° C. The mixture was allowed to stir at room temperature overnight. Methanol was added dropwise to the stirred mixture until visible reaction had ceased. An additional 20 mL of methanol was added and the reaction was stirred for 4 hours. The crude mixture was concentrated, filtered and purified by silica gel chromatography (1:1 heptane:EtOAc as eluant). Fractions containing product were combined and concentrated to give 3-(3-methoxy-phenyl)-propan-1-ol as an oil.

1. temperatureto maintain
2. customreaction temperature below 35° C
3. stirringthe reaction was stirred for 4 hours
4. concentrationThe crude mixture was concentrated
5. filtrationfiltered
6. custompurified by silica gel chromatography (1:1 heptane:EtOAc as eluant)
7. additionFractions containing product
8. concentrationconcentrated

ORD 기록

ord-de7b45d14e284587918e1fd369c6bbd3

출처 데이터셋

uspto-grants-2012_07

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08217027B2