Triethyl methanetricarboxylate → HCID 67232111, compound

HRID 1511919Notes

Reaction equation

[NH2:1][N:2]1[CH:6]=[CH:5][CH:4]=[CH:3]1.[CH2:7]([O:9][C:10](=[O:22])[CH:11]([C:17](OCC)=[O:18])[C:12](OCC)=[O:13])[CH3:8]>>[CH2:7]([O:9][C:10]([C:11]1[C:12](=[O:13])[NH:1][N:2]2[CH:6]=[CH:5][CH:4]=[C:3]2[C:17]=1[OH:18])=[O:22])[CH3:8]

Participants

Reactant 2

HCID 80471Triethyl methanetricarboxylate

HCID 1365891-Aminopyrrole

Product 1

HCID 67232111HCID 67232111, compoundYield 8.1%

Conditions

Temperature: 170 °C

Procedure

A mixture of N-aminopyrrole (1.77 g, 20.56 mmol) and 2-ethoxycarbonyl-malonic acid diethyl ester (14.4 g, 61.68 mmol) was subjected microwave heating at 170° C. for 30 min; then cooled, the reaction mixture was directly purified with silica gel column to give the desired product (372 mg) as brown solid. ESI (m/z): 223 (M+H)+.

Workup

temperaturethen cooled
customthe reaction mixture was directly purified with silica gel column

Sources & evidence

ORD record: ord-826a8ec3d80141beaca8e372b0b659f9
Source dataset: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08217043B2

Reaction notes

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