HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Triethyl methanetricarboxylate → 1-(2-Fluoro-benzyl)-4-hydroxy-2-oxo-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carboxylic acid ethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Triethyl methanetricarboxylate | HCID 80471 | — |
| Edukt | (2-Fluoro-benzyl)-pyrrol-1-yl-carbamic acid tert-butyl ester | HCID 67229820 | — |
| Produkt | 1-(2-Fluoro-benzyl)-4-hydroxy-2-oxo-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carboxylic acid ethyl ester | HCID 67231231 | — |
Reaktionsschritte
Prepared according to the thermal cyclization condition used in Example 1 step c) from (2-fluoro-benzyl)-pyrrol-1-yl-carbamic acid tert-butyl ester (1.0 eq.) and 2-ethoxycarbonyl-malonic acid diethyl ester (3.0 eq.). ESI (m/z): 331 (M+H)+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08217043B2 |
| Quelldatensatz | uspto-grants-2012_07 |
| ORD ID | ord-1d2455a0ae2d4300a549147f93686d66 |
| Quellennotiz | uspto-grants-2012_07 |