Triethyl methanetricarboxylate → HCID 67231559, compound

HRID 1511925Notes

Reaction equation

HRID 1511925 reaction equation
C(O[C:6](=[O:22])[N:7]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=1[F:21])[N:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1)(C)(C)C.[CH2:23]([O:25][C:26](=[O:38])[CH:27](C(OCC)=O)[C:28](OCC)=[O:29])[CH3:24]>>[CH2:23]([O:25][C:26]([C:27]1[C:6](=[O:22])[N:7]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[F:21])[N:8]2[CH:9]=[CH:10][CH:11]=[C:12]2[C:28]=1[OH:29])=[O:38])[CH3:24]

Participants

3

Reactant 2

HCID 80471Triethyl methanetricarboxylateHCID 67229920HCID 67229920, compound

Product 1

HCID 67231559HCID 67231559, compound

Procedure

Prepared according to the thermal cyclization condition used in Example 1 step c) from (2,4-difluoro-benzyl)-pyrrol-1-yl-carbamic acid tert-butyl ester (1.0 eq.) and 2-ethoxycarbonyl-malonic acid diethyl ester (3.0 eq.). ESI (m/z): 349 (M+H)+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-8dfae61d680f4feab139e3533d96a652
Source dataset
uspto-grants-2012_07
Patent number
US08217043B2

Reaction notes

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