Triethyl methanetricarboxylate → HCID 67231338, compound

HRID 1511934Notes

Reaction equation

C(O[C:6](=[O:24])[N:7]([CH2:13][C:14]1[CH:23]=[CH:22][C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:15]=1)[N:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1)(C)(C)C.[CH2:25]([O:27][C:28](=[O:40])[CH:29](C(OCC)=O)[C:30](OCC)=[O:31])[CH3:26]>>[CH2:25]([O:27][C:28]([C:29]1[C:6](=[O:24])[N:7]([CH2:13][C:14]2[CH:23]=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=2)[N:8]2[CH:12]=[CH:11][CH:10]=[C:9]2[C:30]=1[OH:31])=[O:40])[CH3:26]

Participants

Reactant 2

HCID 80471Triethyl methanetricarboxylate

HCID 67230104HCID 67230104, compound

Product 1

HCID 67231338HCID 67231338, compound

Procedure

Prepared according to the thermal cyclization condition used in Example 1 step c) from naphthalen-2-ylmethyl-pyrrol-1-yl-carbamic acid tert-butyl ester (1.0 eq.) and 2-ethoxycarbonyl-malonic acid diethyl ester (3.0 eq.). ESI (m/z): 363 (M+H)+.

Workup

customPrepared

Sources & evidence

ORD record: ord-eedd4b1b1df6430d90f2f0dfea5ee1c4
Source dataset: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08217043B2

Reaction notes

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