Triethyl methanetricarboxylate → HCID 67230485, compound

HRID 1511943Notes

Reaction equation

C(O[C:6](=[O:22])[N:7]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1)[N:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1)(C)(C)C.[CH2:23]([O:25][C:26](=[O:38])[CH:27](C(OCC)=O)[C:28](OCC)=[O:29])[CH3:24]>>[CH2:23]([O:25][C:26]([C:27]1[C:6](=[O:22])[N:7]([CH2:13][C:14]2[CH:15]=[CH:16][C:17]([O:20][CH3:21])=[CH:18][CH:19]=2)[N:8]2[CH:9]=[CH:10][CH:11]=[C:12]2[C:28]=1[OH:29])=[O:38])[CH3:24]

Participants

Reactant 2

HCID 80471Triethyl methanetricarboxylate

HCID 67230419HCID 67230419, compound

Product 1

HCID 67230485HCID 67230485, compound

Procedure

Prepared according to the thermal cyclization condition used in Example 1 step c) from (4-methoxy-benzyl)-pyrrol-1-yl-carbamic acid tert-butyl ester (1.0 eq.) and 2-ethoxycarbonyl-malonic acid diethyl ester (3.0 eq.). ESI (m/z): 343 (M+H)+.

Workup

customPrepared

Sources & evidence

ORD record: ord-741e5c6921ab4ff18af6bdc57c0c40ee
Source dataset: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08217043B2

Reaction notes

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