HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Glycinate → {[1-(2-Trifluoromethyl-benzyl)-4-hydroxy-2-oxo-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carbonyl]-amino}-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Glycinate | HCID 4684308 | — |
| Reactant | 1-(2-Trifluoromethyl-benzyl)-4-hydroxy-2-oxo-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carboxylic acid ethyl ester | HCID 67230354 | — |
| Product | {[1-(2-Trifluoromethyl-benzyl)-4-hydroxy-2-oxo-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carbonyl]-amino}-acetic acid | HCID 54749292 | — |
Reaction Steps
Prepared according to the glycinolysis condition used in Example 1 step d) from 1-(2-trifluoromethyl-benzyl)-4-hydroxy-2-oxo-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carboxylic acid ethyl ester (1.0 eq.) and sodium glycinate (15 eq.). ESI (m/z): 410 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08217043B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-6d175584ebb34488a29a3c0855bc080e |
| Source note | uspto-grants-2012_07 |