L-Alanine → HCID 54751151, compound

Participants

Reaction Steps

A mixture of 4-(4-fluoro-benzyl)-1-hydroxy-3-oxo-3,4-dihydro-4,4a-diaza-fluorene-2-carboxylic acid methyl ester (110 mg), L-alanine (268 mg), NaOMe (146 mg) in 2-methoxyethanol (10 mL) was refluxed for 6 h; subsequently, the reaction was cooled and solvent was removed by rotovaping; the residue was dissolved in water and then acidified with 2 M HCl solution; the precipitates were collected via filtration, washed with water, dried, and then purified with column (eluent: DCM/EtOAc, 10/1 (v/v), with 0.5% acetic acid) to give the desired product (78 mg). ESI (m/z): 424 (M+H)+.

Provenance & Evidence