4-(Trifluoromethyl)benzaldehyde → HCID 67230771, compound

Participants

Reaction Steps

Prepared according to the imine formation condition used in Example 18 step b) from 1-amino-4-chloro-1H-pyrrole-2-carboxylic acid methyl ester (prepared according to literature: Bioorg & Med. Chem. Lett. 2006, 16, 3937-3942) and 4-trifluoromethylbenzaldehyde in refluxing methanol for 12 h. 1H NMR (CDCl3, δ in ppm): 8.43 (s, 1H), 7.95 (d, 2H, J=8.4 Hz), 7.70 (d, 2H, J=7.9 Hz), 7.23 (d, 1H, J=1.6 Hz), 6.91 (d, 1H, J=2.2 Hz), 3.84 (s, 3H).

Provenance & Evidence