L-Alanine → HCID 54751154, compound

HRID 1511973Notes

Reaction equation

HRID 1511973 reaction equation
CO[C:3]([C:5]1[C:10](=[O:11])[N:9]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=2)[N:8]2[CH:23]=[C:24]([Cl:26])[CH:25]=[C:7]2[C:6]=1[OH:27])=[O:4].[NH2:28][C@H:29]([C:31]([OH:33])=[O:32])[CH3:30].C[O-].[Na+]>>[Cl:26][C:24]1[CH:25]=[C:7]2[C:6]([OH:27])=[C:5]([C:3]([NH:28][C@@H:29]([CH3:30])[C:31]([OH:33])=[O:32])=[O:4])[C:10](=[O:11])[N:9]([CH2:12][C:13]3[CH:18]=[CH:17][C:16]([C:19]([F:20])([F:22])[F:21])=[CH:15][CH:14]=3)[N:8]2[CH:23]=1

Participants

4

Reactant 3

HCID 5950L-AlanineHCID 10942334Sodium MethoxideHCID 67230281HCID 67230281, compound

Product 1

HCID 54751154HCID 54751154, compound

Procedure

Prepared according to the reaction condition used in Example 19 step a) from 6-chloro-4-hydroxy-2-oxo-1-(4-trifluoromethyl-benzyl)-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carboxylic acid methyl ester, L-alanine and NaOMe. ESI (m/z): 458 (M+H)+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-446d026f07df49c7b28dce512d5d1ad7
Source dataset
uspto-grants-2012_07
Patent number
US08217043B2

Reaction notes

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