L-Alanine → HCID 54751155, compound

HRID 1511974Notes

Reaction equation

CO[C:3]([C:5]1[C:10](=[O:11])[N:9]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=2)[N:8]2[CH:23]=[CH:24][CH:25]=[C:7]2[C:6]=1[OH:26])=[O:4].[NH2:27][C@H:28]([C:30]([OH:32])=[O:31])[CH3:29].C[O-].[Na+]>>[OH:26][C:6]1[C:7]2[N:8]([CH:23]=[CH:24][CH:25]=2)[N:9]([CH2:12][C:13]2[CH:14]=[CH:15][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:17][CH:18]=2)[C:10](=[O:11])[C:5]=1[C:3]([NH:27][C@@H:28]([CH3:29])[C:30]([OH:32])=[O:31])=[O:4]

Participants

Reactant 3

HCID 5950L-Alanine

HCID 10942334Sodium Methoxide

HCID 68764735HCID 68764735, compound

Product 1

HCID 54751155HCID 54751155, compound

Procedure

Prepared according to the reaction condition used in Example 19 step a) from 4-hydroxy-2-oxo-1-(4-trifluoromethyl-benzyl)-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carboxylic acid methyl ester, L-alanine and NaOMe. ESI (m/z): 424 (M+H)+.

Workup

customPrepared

Sources & evidence

ORD record: ord-0a649322250c430c8e3062a573f39ac2
Source dataset: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08217043B2

Reaction notes

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