(-)-2-Aminobutyric acid → HCID 54751156, compound

HRID 1511975Notes

Reaction equation

HRID 1511975 reaction equation
CO[C:3]([C:5]1[C:10](=[O:11])[N:9]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=2)[N:8]2[CH:23]=[CH:24][CH:25]=[C:7]2[C:6]=1[OH:26])=[O:4].[CH3:27][CH2:28][C@H:29]([NH2:33])[C:30]([OH:32])=[O:31].C[O-].[Na+]>>[OH:26][C:6]1[C:7]2[N:8]([CH:23]=[CH:24][CH:25]=2)[N:9]([CH2:12][C:13]2[CH:14]=[CH:15][C:16]([C:19]([F:22])([F:20])[F:21])=[CH:17][CH:18]=2)[C:10](=[O:11])[C:5]=1[C:3]([NH:33][C@@H:29]([CH2:28][CH3:27])[C:30]([OH:32])=[O:31])=[O:4]

Participants

4

Reactant 3

HCID 80283(-)-2-Aminobutyric acidHCID 10942334Sodium MethoxideHCID 68764735HCID 68764735, compound

Product 1

HCID 54751156HCID 54751156, compound

Procedure

Prepared according to the reaction condition used in Example 19 step a) from 4-hydroxy-2-oxo-1-(4-trifluoromethyl-benzyl)-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carboxylic acid methyl ester, L-2-aminobutyric acid and NaOMe. ESI (m/z): 438 (M+H)+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-9d75238fa81e416e88d3c0e59830321d
Source dataset
uspto-grants-2012_07
Patent number
US08217043B2

Reaction notes

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