4-Fluorobenzaldehyde → HCID 67230731, compound

HRID 1511976Notes

Reaction equation

HRID 1511976 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]([NH2:11])[CH:7]=[C:8]([Cl:10])[CH:9]=1)=[O:4].[F:12][C:13]1[CH:20]=[CH:19][C:16]([CH:17]=O)=[CH:15][CH:14]=1>CO>[CH3:1][O:2][C:3]([C:5]1[N:6]([N:11]=[CH:17][C:16]2[CH:19]=[CH:20][C:13]([F:12])=[CH:14][CH:15]=2)[CH:7]=[C:8]([Cl:10])[CH:9]=1)=[O:4]

Participants

4

Reactant 2

HCID 680234-FluorobenzaldehydeHCID 22180068HCID 22180068, compound

Product 1

HCID 67230731HCID 67230731, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared according to the imine formation condition used in Example 18 step b) from 1-amino-4-chloro-1H-pyrrole-2-carboxylic acid methyl ester and 4-fluoro benzaldehyde in refluxing methanol for 12 h. ESI (m/z): 281 (M+H)+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-8a82fc14ce7d4e82959744c352719007
Source dataset
uspto-grants-2012_07
Patent number
US08217043B2

Reaction notes

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