Methyl malonyl chloride → HCID 67230611, compound

Participants

Reaction Steps

Prepared according to the acylation condition used in Example 2 step f) from 4-chloro-1-(4-chloro-benzylamino)-1H-pyrrole-2-carboxylic acid methyl ester and chlorocarbonyl-acetic acid methyl ester (1.5 eq.). 1H NMR (CDCl3, δ in ppm): 7.26 (d, 2H, J=8.2 Hz), 7.08 (d, 2H, J=8.8 Hz), 6.83 (d, 1H, J=2.2 Hz), 6.47 (d, 1H, J=1.8 Hz), 5.27 (d, 1H, J=14.6 Hz), 4.27 (d, 1H, J=14.6 Hz), 3.75 (s, 3H), 3.69 (s, 3H), 3.18 (m, 2H).

Provenance & Evidence