Methyl malonyl chloride → HCID 67229988, compound

HRID 1511984Notes

Reaction equation

HRID 1511984 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]([NH:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)[CH:7]=[C:8]([Cl:10])[CH:9]=1)=[O:4].[CH3:21][O:22][C:23](=[O:28])[CH2:24][C:25](Cl)=[O:26]>>[CH3:1][O:2][C:3]([C:5]1[N:6]([N:11]([C:25](=[O:26])[CH2:24][C:23]([O:22][CH3:21])=[O:28])[CH2:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)[CH:7]=[C:8]([Cl:10])[CH:9]=1)=[O:4]

Participants

3

Reactant 2

HCID 123460Methyl malonyl chlorideHCID 67231349HCID 67231349, compound

Product 1

HCID 67229988HCID 67229988, compound

Procedure

Prepared according to the acylation condition used in Example 2 step f) from 4-chloro-1-(4-methoxy-benzylamino)-1H-pyrrole-2-carboxylic acid methyl ester and chlorocarbonyl-acetic acid methyl ester (1.5 eq.). ESI (m/z): 395 (M+H)+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-774f55ad20c04791bf00fadcf65e85af
Source dataset
uspto-grants-2012_07
Patent number
US08217043B2

Reaction notes

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