L-Alanine → HCID 54751162, compound

HRID 1511986Notes

Reaction equation

HRID 1511986 reaction equation
CO[C:3]([C:5]1[C:10](=[O:11])[N:9]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)[N:8]2[CH:21]=[C:22]([Cl:24])[CH:23]=[C:7]2[C:6]=1[OH:25])=[O:4].[NH2:26][C@H:27]([C:29]([OH:31])=[O:30])[CH3:28].C[O-].[Na+]>>[Cl:24][C:22]1[CH:23]=[C:7]2[C:6]([OH:25])=[C:5]([C:3]([NH:26][C@@H:27]([CH3:28])[C:29]([OH:31])=[O:30])=[O:4])[C:10](=[O:11])[N:9]([CH2:12][C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=3)[N:8]2[CH:21]=1

Participants

4

Reactant 3

HCID 5950L-AlanineHCID 10942334Sodium MethoxideHCID 67229790HCID 67229790, compound

Product 1

HCID 54751162HCID 54751162, compound

Procedure

Prepared according to the reaction condition used in Example 19 step a) from 6-chloro-4-hydroxy-2-oxo-1-(4-methoxy-benzyl)-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carboxylic acid methyl ester, L-alanine and NaOMe. ESI (m/z): 420 (M+H)+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-336a3adacacc4c78ac4749b034fd02e8
Source dataset
uspto-grants-2012_07
Patent number
US08217043B2

Reaction notes

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