L-Alanine → HCID 54751165, compound

HRID 1511989Notes

Reaction equation

HRID 1511989 reaction equation
CO[C:3]([C:5]1[C:10](=[O:11])[N:9]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[CH:15][CH:14]=2)[N:8]2[CH:25]=[C:26]([Cl:28])[CH:27]=[C:7]2[C:6]=1[OH:29])=[O:4].[NH2:30][C@H:31]([C:33]([OH:35])=[O:34])[CH3:32].C[O-].[Na+]>>[C:16]1([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:15]=[CH:14][C:13]([CH2:12][N:9]2[C:10](=[O:11])[C:5]([C:3]([NH:30][C@@H:31]([CH3:32])[C:33]([OH:35])=[O:34])=[O:4])=[C:6]([OH:29])[C:7]3=[CH:27][C:26]([Cl:28])=[CH:25][N:8]23)=[CH:18][CH:17]=1

Participants

4

Reactant 3

HCID 5950L-AlanineHCID 10942334Sodium MethoxideHCID 67230597HCID 67230597, compound

Product 1

HCID 54751165HCID 54751165, compound

Procedure

Prepared according to the reaction condition used in Example 19 step a) from 1-biphenyl-4-ylmethyl-6-chloro-4-hydroxy-2-oxo-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carboxylic acid methyl ester, L-alanine and NaOMe. ESI (m/z): 466 (M+H)+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-1d45aefe93cb41a8a1566b0fb6985cb0
Source dataset
uspto-grants-2012_07
Patent number
US08217043B2

Reaction notes

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