HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Glycinate → {[6,7-Dichloro-1-(4-fluoro-benzyl)-4-hydroxy-2-oxo-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carbonyl]-amino}-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Glycinate | HCID 4684308 | — |
| Reactant | 6,7-Dichloro-1-(4-fluoro-benzyl)-4-hydroxy-2-oxo-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carboxylic acid methyl ester | HCID 67230919 | — |
| Product | {[6,7-Dichloro-1-(4-fluoro-benzyl)-4-hydroxy-2-oxo-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carbonyl]-amino}-acetic acid | HCID 54751172 | — |
Reaction Steps
Prepared according to the glycinolysis condition used in Example 1 step d) from 6,7-Dichloro-1-(4-fluoro-benzyl)-4-hydroxy-2-oxo-1,2-dihydro-pyrrolo[1,2-b]pyridazine-3-carboxylic acid methyl ester (1.0 eq.) and sodium glycinate (5 eq.). ESI (m/z): 428 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08217043B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-ceca9f8fea9c480e97728f5066844bf3 |
| Source note | uspto-grants-2012_07 |