HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → Z-6-chloro-3-cyclopent-1-enylmethylene-1,3-dihydro-indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 1-Cyclopentene-1-carboxaldehyde | HCID 138672 | — |
| Reactant | 6-Chloro-1,3-dihydroindol-2-one | HCID 736344 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Z-6-chloro-3-cyclopent-1-enylmethylene-1,3-dihydro-indol-2-one | HCID 68796311 | 30.7% |
Reaction Steps
In a manner similar to the method described in Example 1, 6-chlorooxindole (2.51 g, 15 mmol) (Alfa) was reacted with cyclopent-1-enecarbaldehyde (1.45 g, 15 mmol) (Aldrich) and piperidine (1.49 mL, 15 mmol) in methanol to give E/Z-6-chloro-3-cyclopent-1-enylmethylene-1,3-dihydro-indol-2-one as a yellow solid (Yield 1.13 g, 30%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08217051B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-70d16a9661234fd598d37a6bdf73221e |
| Source note | uspto-grants-2012_07 |