Ethylene Glycol → Ethyl 1,4-dioxaspiro(4.5)decane-8-carboxylate

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Reaction Steps

A solution of 4-oxo-cyclohexanecarboxylic acid ethyl ester (5.0 g, 29.4 mmol), ethylene glycol (5.7 mL, 102 mmol) and p-toluenesulfonic acid (0.067 g, 0.35 mmol) in toluene (15 mL) was stirred at room temperature for 18 h. The resulting solution was diluted with ethyl ether (20 mL). The organic layer was washed successively with water and brine, separated and dried with sodium sulfate, filtered and concentrated to yield 1,4-dioxa-spiro[4.5]decane-8-carboxylic acid ethyl ester.

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