反应详情

(E)-2-(2-Cyclohexyl-propenyl)-5-(2-trifluoromethyl-phenyl)-1H-benzimidazole was prepared from 3-(4,4-difluoro-cyclohexyl)-acryloyl chloride (prepared from 4,4-difluoro-cyclohexanecarboxylic acid ethyl ester utilizing a procedure analogous to the preparation of 4-methyl-tetrahydro-pyran-4-carbaldehyde in Example 9) and 3-nitro-2′-trifluoromethyl-biphenyl-4-ylamine (prepared as described in Example 3, STEP A) as described in Example 9, STEPS A-C.