反应详情

(E)-2-[2-(4-Bromo-bicyclo[2.2.2]oct-1-yl)-vinyl]-5-(2-trifluoromethyl-phenyl)-1H-benzoimidazole was prepared from 3-(4-bromo-bicyclo[2.2.2]oct-1-yl)-acryloyl chloride (prepared from 4-bromo-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester utilizing a procedure analogues to the preparation of 4-methyl-tetrahydro-pyran-4-carbaldehyde in Example 9) and 3-nitro-2′-trifluoromethyl-biphenyl-4-ylamine (prepared as described in Example 3, STEP A) according to the procedure as described in Example 9, STEPS A-C.