反应详情

13.07 g (60.6 mmol) of pyridinium chlorochromate (PCC) are added to a solution of 18.02 g (50.5 mmol) of dimethyl 4,4′-[2-(hydroxymethyl)butane-1,4-diyl]dibenzoate in 350 ml of dichloromethane, and the mixture is stirred at room temperature for 12 hours. After the reaction has gone to completion, about 60 g of silica gel are added and the solvent is removed to dryness under reduced pressure. The residue is purified by flash chromatography on silica gel (mobile phase: cyclohexane/ethyl acetate 5:1→4:1). This gives 14.73 g (41.46 mmol, 82% of theory) of a colorless oil.

1. additionare added
2. customthe solvent is removed to dryness under reduced pressure
3. customThe residue is purified by flash chromatography on silica gel (mobile phase: cyclohexane/ethyl acetate 5:1→4:1)