反应详情

温度

60 °C

A solution of 82.0 mg (0.288 mmol) of 2-(2-oxo-1,3-oxazolidin-3-yl)ethyl 4-methylbenzenesulfonate [CAS Reg. No. 159974-55-7] is initially charged in 1.5 ml of dry toluene, and 187 mg (0.576 mmol) of cesium carbonate are added. 32 mg (0.072 mmol) of methyl 4-{(4E)-5-(2-hydroxy-phenyl)-3-[4-(methoxycarbonyl)benzyl]pent-4-en-1-yl}benzoate (racemate; Example 18A) are then added. The reaction mixture is stirred at 60° C. for 18 h and then carefully poured into 15 ml of ice-cold 10% strength ammonium chloride solution. The mixture is extracted twice with ethyl acetate. The combined organic phases are dried over sodium sulfate, filtered and concentrated. This gives 39 mg (0.070 mmol, 97% of theory) of a colorless oil which is reacted without further purification

1. extractionThe mixture is extracted twice with ethyl acetate
2. dry with materialThe combined organic phases are dried over sodium sulfate
3. filtrationfiltered
4. concentrationconcentrated
5. customThis gives 39 mg (0.070 mmol, 97% of theory) of a colorless oil which is reacted without further purification