3-Piperidinol, 1-methyl- → 2-(1-Methyl-piperidin-3-yloxy)-nicotinonitrile

HRID 1512249Notes

Reaction equation

HRID 1512249 reaction equation
F[C:2]1[N:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[CH3:10][N:11]1[CH2:16][CH2:15][CH2:14][CH:13]([OH:17])[CH2:12]1>>[CH3:10][N:11]1[CH2:16][CH2:15][CH2:14][CH:13]([O:17][C:2]2[N:9]=[CH:8][CH:7]=[CH:6][C:3]=2[C:4]#[N:5])[CH2:12]1

Participants

3

Reactant 2

HCID 980163-Piperidinol, 1-methyl-HCID 27832543-Cyano-2-fluoropyridine

Product 1

HCID 685826862-(1-Methyl-piperidin-3-yloxy)-nicotinonitrile

Procedure

2-Fluoro-nicotinonitrile was reacted with 1-methyl-piperidin-3-ol according to the method of Example 85A to provide the title compound. MS (DCI/NH3) m/z 218 (M+1)+.

Sources & evidence

ORD record
ord-dd8f804abcb3413bb65acdb952bc84fd
Source dataset
uspto-grants-2012_07
Patent number
US08217067B2

Reaction notes

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